Research workbench
Rat PP1CGAMMA complexed with mouse inhibitor-2
Analyse Rat PP1CGAMMA complexed with mouse inhibitor-2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2O8A
- Type
- protein
- Length
- 707 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase…
- EC
- 3.1.3.16
- UniProt
- P63088, Q9DCL8
- Pockets
- 6 · best druggability 0.59
Structure
x-ray diffraction · 3 distinct chains · 42% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | SERINE/THREONINE-protein phosphatase PP1-gamma catalytic subunit (EC 3.1.3.16) | protein | 295 | 34% helix, 20% strand | P63088 |
| I | Protein phosphatase inhibitor 2 | protein | 59 | 63% helix, 5% strand | Q9DCL8 |
| J | Protein phosphatase inhibitor 2 | protein | 58 | 64% helix, 5% strand | Q9DCL8 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 269 | 0.59 | 0.78 | 31 | empty |
| 2 | 249 | 0.59 | 0.79 | 28 | empty |
| 3 | 90 | 0.33 | 0.74 | 17 | empty |
| 4 | 85 | 0.33 | 0.74 | 17 | empty |
| 5 | 54 | 0.30 | 0.76 | 16 | empty |
Interfaces
2 interfaces between chains.
- A–I · 2327 Ų buried · 38 hydrogen bonds · protein-protein
- B–J · 2308 Ų buried · 39 hydrogen bonds · protein-protein
Compared structures
- 2O8A · rat PP1cgamma complexed with mouse inhibitor-2 · the same entry in another collection · chain A against A, TM-score 1.00
- P63088 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase PP1-gamma… · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q9DCL8 · AlphaFold monomer V2.0 prediction for protein phosphatase inhibitor 2 (Q9DCL8) · a predicted model of the same protein · chain J against A, TM-score 0.47
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63088
- Every structure of UniProt Q9DCL8
- Elsewhere: RCSB PDB 2O8A · PDBe 2O8A · UniProt P63088 · UniProt Q9DCL8
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