Research workbench
Crystal structure of irf-3 bound to the interferon-B enhancer
Analyse Crystal structure of irf-3 bound to the interferon-B enhancer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2O6G
- Type
- protein + DNA
- Length
- 550 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interferon-B enhancer; Interferon regulatory factor 3
- UniProt
- Q14653
- Pockets
- 15 · best druggability 0.62
Structure
x-ray diffraction · 4 distinct chains · 33% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D | Interferon-B enhancer | dna | 57 | — | — |
| C | Interferon-B enhancer | dna | 57 | — | — |
| E, G | Interferon regulatory factor 3 | protein | 110 | 31% helix, 10% strand | Q14653 |
| F, H | Interferon regulatory factor 3 | protein | 108 | 35% helix, 19% strand | Q14653 |
Pockets
15 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 360 | 0.62 | 0.78 | 49 | empty |
| 2 | 323 | 0.58 | 0.77 | 37 | empty |
| 3 | 392 | 0.58 | 0.75 | 41 | empty |
| 4 | 309 | 0.57 | 0.77 | 39 | empty |
| 5 | 260 | 0.55 | 0.78 | 32 | empty |
Interfaces
11 interfaces between chains.
- D–C · 2481 Ų buried · 236 hydrogen bonds · nucleic-nucleic
- C–F · 716 Ų buried · 8 hydrogen bonds · protein-nucleic
- C–G · 698 Ų buried · 11 hydrogen bonds · protein-nucleic
- C–H · 653 Ų buried · 12 hydrogen bonds · protein-nucleic
- C–E · 646 Ų buried · 9 hydrogen bonds · protein-nucleic
Compared structures
- 2O6G · Crystal structure of IRF-3 bound to the interferon-b enhancer · the same entry in another collection · chain H against H, TM-score 1.00
- Q14653 · AlphaFold monomer V2.0 prediction for interferon regulatory factor 3 (Q14653) · a predicted model of the same protein · chain F against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14653
- Elsewhere: RCSB PDB 2O6G · PDBe 2O6G · UniProt Q14653
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.