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Crystal structure of human P100 tudor domain

Analyse Crystal structure of human P100 tudor domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2O4X
Type: protein
Length: 304 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Staphylococcal nuclease domain-containing protein 1
UniProt: Q7KZF4
Pockets: 2 · best druggability 0.50

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Staphylococcal nuclease domain-containing protein 1	protein	217	32% helix, 30% strand	Q7KZF4
B	Staphylococcal nuclease domain-containing protein 1	protein	87	24% helix, 32% strand	Q7KZF4

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	144	0.50	0.79	24	empty
2	125	0.38	0.73	24	empty

Interfaces

1 interface between chains.

A–B · 453 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

2O4X · Crystal structure of human P100 tudor domain · the same entry in another collection · chain A against A, TM-score 1.00
Q7KZF4 · AlphaFold monomer V2.0 prediction for staphylococcal nuclease domain- containing protein… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7KZF4
Elsewhere: RCSB PDB 2O4X · PDBe 2O4X · UniProt Q7KZF4

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