Research workbench
Crystal structure of M11L, BCL-2 homolog from myxoma virus
Analyse Crystal structure of M11L, BCL-2 homolog from myxoma virus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2O42
- Type
- protein
- Length
- 265 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- M11L protein
- UniProt
- Q85295
- Pockets
- 2 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | M11L protein | protein | 138 | 75% helix, 0% strand | Q85295 |
| B | M11L protein | protein | 127 | 76% helix, 0% strand | Q85295 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 66 | 0.48 | 0.84 | 18 | empty |
| 2 | 57 | 0.29 | 0.74 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 898 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified, 2 disulfide (engineered, disulfide).
Compared structures
- 2O42 · Crystal Structure of M11L, Bcl-2 homolog from myxoma virus · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q85295
- Elsewhere: RCSB PDB 2O42 · PDBe 2O42 · UniProt Q85295
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