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Mycobacterium tuberculosis tryptophan synthase beta chain dimer (apoform)

Analyse Mycobacterium tuberculosis tryptophan synthase beta chain dimer (apoform) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2O2J
Type: protein
Length: 631 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tryptophan synthase beta chain
EC: 4.2.1.20
UniProt: P66984
Pockets: 11 · best druggability 0.69

Structure

x-ray diffraction · 2 distinct chains · 50% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tryptophan synthase beta chain (EC 4.2.1.20)	protein	315	51% helix, 16% strand	P66984
B	Tryptophan synthase beta chain (EC 4.2.1.20)	protein	316	49% helix, 16% strand	P66984

Pockets

11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	365	0.69	0.82	36	empty
2	355	0.67	0.81	46	empty
3	329	0.65	0.80	26	empty
4	157	0.56	0.81	33	empty
5	161	0.48	0.77	29	empty

Interfaces

1 interface between chains.

A–B · 1540 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

2O2J · Mycobacterium tuberculosis tryptophan synthase beta chain dimer (apoform) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P66984
Elsewhere: RCSB PDB 2O2J · PDBe 2O2J · UniProt P66984

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