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The crystal structure of a protein of unknown function from streptococcus agalactiae

Analyse The crystal structure of a protein of unknown function from streptococcus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2O2A
Type: protein
Length: 501 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hypothetical protein GBS1413
UniProt: Q8E4I8
Pockets: 3 · best druggability 0.83

Structure

x-ray diffraction · 3 distinct chains · 30% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hypothetical protein GBS1413	protein	125	29% helix, 41% strand	Q8E4I8
B, C	Hypothetical protein GBS1413	protein	126	30% helix, 41% strand	Q8E4I8
D	Hypothetical protein GBS1413	protein	124	30% helix, 43% strand	Q8E4I8

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	398	0.83	0.91	64	empty
2	211	0.68	0.85	35	empty
3	100	0.66	0.90	22	empty

Interfaces

6 interfaces between chains.

B–D · 1384 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 924 Å² buried · 16 hydrogen bonds · protein-protein
C–D · 915 Å² buried · 16 hydrogen bonds · protein-protein
A–D · 764 Å² buried · 4 hydrogen bonds · protein-protein
B–C · 760 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 modified (engineered).

Compared structures

2O2A · The crystal structure of a protein of unknown function from Streptococcus agalactiae · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8E4I8
Elsewhere: RCSB PDB 2O2A · PDBe 2O2A · UniProt Q8E4I8

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