Research workbench
The crystal structure of athe putative tetr-family transcriptional regulator RHA06780 from rhodococcus sp. RHA1.
Analyse The crystal structure of athe putative tetr-family transcriptional regulator… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2NX4
- Type
- protein
- Length
- 762 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional regulator, tetr family protein
- UniProt
- Q0SCU8
- Pockets
- 5 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Transcriptional regulator, tetr family protein | protein | 194 | 78% helix, 0% strand | Q0SCU8 |
| C, D | Transcriptional regulator, tetr family protein | protein | 187 | 78% helix, 0% strand | Q0SCU8 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 908 | 0.79 | 0.81 | 108 | empty |
| 2 | 111 | 0.58 | 0.85 | 30 | empty |
| 3 | 129 | 0.54 | 0.82 | 32 | empty |
| 4 | 81 | 0.49 | 0.82 | 18 | empty |
| 5 | 72 | 0.45 | 0.81 | 17 | empty |
Interfaces
5 interfaces between chains.
- C–D · 1943 Ų buried · 25 hydrogen bonds · protein-protein
- A–B · 1942 Ų buried · 20 hydrogen bonds · protein-protein
- A–D · 671 Ų buried · 9 hydrogen bonds · protein-protein
- B–D · 162 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 113 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2NX4 · The Crystal Structure of athe Putative TetR-family transcriptional regulator Rha06780… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q0SCU8
- Elsewhere: RCSB PDB 2NX4 · PDBe 2NX4 · UniProt Q0SCU8
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