Research workbench
Molecular structures of the complexes of sgpb with OMTKY3 aromatic P1 variants TRP18I, HIS18I, PHE18I and TYR18I
Analyse Molecular structures of the complexes of sgpb with OMTKY3 aromatic P1 variants… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2NU1
- Type
- protein
- Length
- 236 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Streptogrisin B; Ovomucoid
- EC
- 3.4.21.81
- UniProt
- P00777, P68390
- Pockets
- 2 · best druggability 0.41
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | Streptogrisin B (EC 3.4.21.81) | protein | 185 | 6% helix, 53% strand | P00777 |
| I | Ovomucoid | protein | 51 | 20% helix, 24% strand | P68390 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 130 | 0.41 | 0.75 | 25 | empty |
| 2 | 97 | 0.38 | 0.76 | 16 | empty |
Interfaces
1 interface between chains.
- E–I · 660 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 2NU1 · Molecular structures of the complexes of SGPB with OMTKY3 aromatic P1 variants Trp18I… · the same entry in another collection · chain E against E, TM-score 1.00
- P00777 · AlphaFold monomer V2.0 prediction for streptogrisin-B (P00777) · a predicted model of the same protein · chain E against A, TM-score 0.99
- P68390 · AlphaFold monomer V2.0 prediction for ovomucoid (P68390) · a predicted model of the same protein · chain I against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00777
- Every structure of UniProt P68390
- Elsewhere: RCSB PDB 2NU1 · PDBe 2NU1 · UniProt P00777 · UniProt P68390
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.