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Crystal structure of N-acetyl-gamma-glutamyl-phosphate reductase (RV1652) from mycobacterium tuberculosis at 1.58 a resolution
Analyse Crystal structure of N-acetyl-gamma-glutamyl-phosphate reductase (RV1652) from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2NQT
- Type
- protein
- Length
- 692 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- N-acetyl-gamma-glutamyl-phosphate reductase
- EC
- 1.2.1.38
- UniProt
- P63562
- Pockets
- 10 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) | protein | 347 | 32% helix, 22% strand | P63562 |
| B | N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) | protein | 345 | 32% helix, 22% strand | P63562 |
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 279 | 0.61 | 0.79 | 52 | empty |
| 2 | 284 | 0.59 | 0.78 | 48 | empty |
| 3 | 161 | 0.59 | 0.83 | 24 | empty |
| 4 | 84 | 0.40 | 0.78 | 18 | empty |
| 5 | 95 | 0.40 | 0.77 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1772 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (oxidation).
Compared structures
- 2NQT · Crystal structure of N-Acetyl-gamma-Glutamyl-Phosphate Reductase (Rv1652) from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63562
- Elsewhere: RCSB PDB 2NQT · PDBe 2NQT · UniProt P63562
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