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Crystal structure of methyltransferase from streptococcus mutans

Analyse Crystal structure of methyltransferase from streptococcus mutans in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2NQ5
Type: protein
Length: 706 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
EC: 2.1.1.14
UniProt: Q8CWX6
Pockets: 9 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	protein	706	46% helix, 15% strand	Q8CWX6

Pockets

9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	632	0.77	0.82	60	empty
2	67	0.73	0.98	21	empty
3	126	0.68	0.90	21	empty
4	487	0.65	0.77	42	empty
5	230	0.57	0.79	21	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

2NQ5 · Crystal structure of methyltransferase from Streptococcus mutans · the same entry in another collection · chain A against A, TM-score 1.00
Q8CWX6 · AlphaFold monomer V2.0 prediction for 5-methyltetrahydropteroyltriglutamate--homocysteine… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8CWX6
Elsewhere: RCSB PDB 2NQ5 · PDBe 2NQ5 · UniProt Q8CWX6

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