Research workbench
An unusual twin-his arrangement in the pore of ammonia channels is essential for substrate conductance
Analyse An unusual twin-his arrangement in the pore of ammonia channels is essential… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2NPK
- Type
- protein
- Length
- 376 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ammonia channel
- UniProt
- P69681
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.55
Structure
x-ray diffraction · 1 distinct chain · 74% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ammonia channel | protein | 376 | 74% helix, 2% strand | P69681 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A
- ACT · Acetate ion · additive · chains A
- IMD · Imidazole · additive · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 150 | 0.55 | 0.81 | 30 | SO4 |
| 2 | 174 | 0.48 | 0.76 | 27 | ACT, IMD, GOL |
Compared structures
- 2NPK · An unusual twin-His arrangement in the pore of ammonia channels is essential for… · the same entry in another collection · chain A against A, TM-score 1.00
- P69681 · AlphaFold monomer V2.0 prediction for ammonia channel (P69681) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P69681
- Elsewhere: RCSB PDB 2NPK · PDBe 2NPK · UniProt P69681
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