Research workbench

An unusual twin-his arrangement in the pore of ammonia channels is essential for substrate conductance

Analyse An unusual twin-his arrangement in the pore of ammonia channels is essential… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2NPD
Type: protein
Length: 368 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ammonia channel
UniProt: P69681
Pockets: 3 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 76% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ammonia channel	protein	368	76% helix, 2% strand	P69681

Ligands and binding sites

ACT · Acetate ion · additive · chains A
IMD · Imidazole · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	91	0.56	0.85	19	empty
2	167	0.48	0.76	27	ACT, IMD
3	51	0.36	0.79	12	empty

Compared structures

2NPD · An unusual twin-His arrangement in the pore of ammonia channels is essential for… · the same entry in another collection · chain A against A, TM-score 1.00
P69681 · AlphaFold monomer V2.0 prediction for ammonia channel (P69681) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P69681
Elsewhere: RCSB PDB 2NPD · PDBe 2NPD · UniProt P69681

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.