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Human beta-defensin-1 (mutant GLN11ALA)

Analyse Human beta-defensin-1 (mutant GLN11ALA) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2NLE
Type: protein
Length: 72 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-defensin 1
UniProt: P60022
Ligands: SO4

Structure

x-ray diffraction · 1 distinct chain · 17% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Beta-defensin 1	protein	36	17% helix, 33% strand	P60022

Ligands and binding sites

SO4 · Sulfate ion · ion · 3 copies · chains A, B
ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 42 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

2NLE · Human beta-defensin-1 (Mutant Gln11Ala) · the same entry in another collection · chain A against A, TM-score 1.00
P60022 · AlphaFold monomer V2.0 prediction for beta-defensin 1 (P60022) · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P60022
Elsewhere: RCSB PDB 2NLE · PDBe 2NLE · UniProt P60022

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