Research workbench
Crystal structure of the mcl-1:MNOXAB BH3 complex
Analyse Crystal structure of the mcl-1:MNOXAB BH3 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2NLA
- Type
- protein
- Length
- 171 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion protein consisting of induced myeloid leukemia cell differentiation protein mcl-1…
- UniProt
- P97287, Q07820, Q9JM54
- Pockets
- 1 · best druggability 0.37
Structure
x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fusion protein consisting of induced myeloid leukemia cell differentiation protein mcl-1 homolog | protein | 150 | 78% helix, 0% strand | P97287, Q07820 |
| B | Phorbol-12-myristate-13-acetate-induced protein 1 | protein | 21 | 67% helix, 0% strand | Q9JM54 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 86 | 0.37 | 0.76 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 838 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 2NLA · Crystal structure of the Mcl-1:mNoxaB BH3 complex · the same entry in another collection · chain A against A, TM-score 1.00
- P97287 · AlphaFold monomer V2.0 prediction for induced myeloid leukemia cell differentiation… · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q07820 · AlphaFold monomer V2.0 prediction for induced myeloid leukemia cell differentiation… · a predicted model of the same protein · chain A against A, TM-score 0.96
- Q9JM54 · AlphaFold monomer V2.0 prediction for phorbol-12-myristate-13-acetate-induced protein 1… · a predicted model of the same protein · chain B against A, TM-score 0.60
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P97287
- Every structure of UniProt Q07820
- Every structure of UniProt Q9JM54
- Elsewhere: RCSB PDB 2NLA · PDBe 2NLA · UniProt P97287 · UniProt Q07820 · UniProt Q9JM54
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