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Lysine dimethylated FKBP12

Analyse Lysine dimethylated FKBP12 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2ND5
Type: protein
Length: 111 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peptidyl-prolyl cis-trans isomerase FKBP1A
EC: 5.2.1.8
UniProt: P62942
Pockets: 1 · best druggability 0.36

Structure

solution nmr · 1 distinct chain · 14% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Peptidyl-prolyl cis-trans isomerase FKBP1A (EC 5.2.1.8)	protein	111	14% helix, 36% strand	P62942

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	74	0.36	0.76	14	empty

Modifications

Observed in the structure: 8 modified (methylation).

Compared structures

2ND5 · Lysine dimethylated FKBP12 · the same entry in another collection · chain A against A, TM-score 1.00
P62942 · AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase FKBP1A (P62942) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62942
Elsewhere: RCSB PDB 2ND5 · PDBe 2ND5 · UniProt P62942

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