Research workbench
Zipcode-binding-protein-1 KH3(DD)KH4 domains in complex with the KH4 RNA target
Analyse Zipcode-binding-protein-1 KH3(DD)KH4 domains in complex with the KH4 RNA target in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2N8M
- Type
- protein + RNA
- Length
- 198 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin-like growth factor 2 mRNA-binding protein 1; RNA (5'-R(P*UP*CP*GP*GP*AP*CP*U)-3')
- UniProt
- O42254
- Pockets
- 2 · best druggability 0.45
Structure
solution nmr · 2 distinct chains · 39% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin-like growth factor 2 mRNA-binding protein 1 | protein | 191 | 39% helix, 18% strand | O42254 |
| B | RNA (5'-R(P*UP*CP*GP*GP*AP*CP*U)-3') | rna | 7 | — | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 124 | 0.45 | 0.77 | 21 | empty |
| 2 | 111 | 0.40 | 0.76 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 593 Ų buried · 14 hydrogen bonds · protein-nucleic
Compared structures
- 2N8M · Zipcode-binding-protein-1 KH3(DD)KH4 domains in complex with the KH4 RNA target · the same entry in another collection · chain A against A, TM-score 1.00
- O42254 · AlphaFold monomer V2.0 prediction for insulin-like growth factor 2 mRNA-binding protein 1… · a predicted model of the same protein · chain A against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O42254
- Elsewhere: RCSB PDB 2N8M · PDBe 2N8M · UniProt O42254
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