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Cystein knot with 2FP integrin AVB6 cancer recognition site

Analyse Cystein knot with 2FP integrin AVB6 cancer recognition site in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
2N8C
Type
protein
Length
36 residues
Chains
1
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Cysteine knot
Ligands
4LT

Structure

solution nmr · 1 distinct chain · 17% helix, 11% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ACysteine knotprotein3617% helix, 11% strand—

Ligands and binding sites

  • 4LT · (2R)-2-fluoropropanoic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Modifications

Observed in the structure: 3 disulfide, 1 covalent (disulfide, covalent ligand).

Compared structures

  • 2N8C · Cystein knot with 2fp integrin avb6 cancer recognition site · the same entry in another collection · chain A against A, TM-score 1.00

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