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Human BRD4 et domain in complex with mlv integrase C-term

Analyse Human BRD4 et domain in complex with mlv integrase C-term in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
2N3K
Type
protein
Length
96 residues
Chains
2
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Bromodomain-containing protein 4; Mlv integrase
UniProt
O60885, Q8UN00

Structure

solution nmr · 2 distinct chains · 44% helix, 15% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ABromodomain-containing protein 4protein7953% helix, 6% strandO60885
BMlv integraseprotein170% helix, 53% strandQ8UN00

Interfaces

1 interface between chains.

  • A–B · 801 Ų buried · 9 hydrogen bonds · protein-protein

Compared structures

  • 2N3K · Human Brd4 ET domain in complex with MLV Integrase C-term · the same entry in another collection · chain A against A, TM-score 1.00
  • O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.82

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