Research workbench
Solution structure of SDS3 in complex with SIN3A
Analyse Solution structure of SDS3 in complex with SIN3A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2N2H
- Type
- protein
- Length
- 152 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SIN3 histone deacetylase corepressor complex component SDS3; Paired amphipathic helix…
- UniProt
- Q8BR65, Q60520
- Pockets
- 1 · best druggability 0.53
Structure
solution nmr · 2 distinct chains · 66% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SIN3 histone deacetylase corepressor complex component SDS3 | protein | 27 | 41% helix, 0% strand | Q8BR65 |
| B | Paired amphipathic helix protein SIN3A | protein | 125 | 71% helix, 0% strand | Q60520 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 61 | 0.53 | 0.87 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 886 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 2N2H · Solution structure of Sds3 in complex with Sin3A · the same entry in another collection · chain A against A, TM-score 1.00
- Q60520 · AlphaFold monomer V2.0 prediction for paired amphipathic helix protein SIN3A (Q60520) · a predicted model of the same protein · chain B against A, TM-score 0.78
- Q8BR65 · AlphaFold monomer V2.0 prediction for SIN3 histone deacetylase corepressor complex… · a predicted model of the same protein · chain A against A, TM-score 0.59
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8BR65
- Every structure of UniProt Q60520
- Elsewhere: RCSB PDB 2N2H · PDBe 2N2H · UniProt Q8BR65 · UniProt Q60520
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