Research workbench
Crystal structure of giardia guanine phosphoribosyltransferase complexed with immucilling
Analyse Crystal structure of giardia guanine phosphoribosyltransferase complexed with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1DQP
- Type
- protein
- Length
- 460 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine phosphoribosyltransferase
- EC
- 2.4.2.8
- UniProt
- Q24973
- Ligands
- IMG
- Pockets
- 9 · best druggability 0.61
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Guanine phosphoribosyltransferase (EC 2.4.2.8) | protein | 230 | 36% helix, 23% strand | Q24973 |
Ligands and binding sites
- IMG · 1,4-dideoxy-1,4-imino-1-(S)-(9-deazaguanin-9-yl)-D-ribitol · ligand · 2 copies · chains A, B
- IPA · Isopropyl alcohol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 245 | 0.61 | 0.80 | 35 | empty |
| 2 | 277 | 0.57 | 0.77 | 33 | IMG |
| 3 | 281 | 0.56 | 0.77 | 31 | IMG |
| 4 | 93 | 0.35 | 0.74 | 17 | empty |
| 5 | 87 | 0.34 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1790 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 1DQP · Crystal structure of giardia guanine phosphoribosyltransferase complexed with immucilling · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q24973
- Elsewhere: RCSB PDB 1DQP · PDBe 1DQP · UniProt Q24973
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.