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Structural insights of tm domain of lamp-2A in dpc micelles

Analyse Structural insights of tm domain of lamp-2A in dpc micelles in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2MOM
Type: protein
Length: 126 residues
Chains: 3
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lysosome-associated membrane glycoprotein 2
UniProt: P13473
Pockets: 2 · best druggability 0.58

Structure

solution nmr · 1 distinct chain · 50% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Lysosome-associated membrane glycoprotein 2	protein	42	50% helix, 0% strand	P13473

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	416	0.58	0.74	37	empty
2	255	0.55	0.77	33	empty

Interfaces

3 interfaces between chains.

A–B · 391 Å² buried · 1 hydrogen bond · protein-protein
B–C · 244 Å² buried · 0 hydrogen bonds · protein-protein
A–C · 239 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

2MOM · Structural insights of TM domain of LAMP-2A in DPC micelles · the same entry in another collection · chain A against A, TM-score 1.00
P13473 · AlphaFold monomer V2.0 prediction for lysosome-associated membrane glycoprotein 2 (P13473) · a predicted model of the same protein · chain A against A, TM-score 0.54

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P13473
Elsewhere: RCSB PDB 2MOM · PDBe 2MOM · UniProt P13473

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