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NMR structure of E. COLI trigger factor in complex with unfolded PHOA220-310

Analyse NMR structure of E. COLI trigger factor in complex with unfolded PHOA220-310 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2MLX
Type: protein
Length: 523 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Trigger factor; Alkaline phosphatase
EC: 5.2.1.8
UniProt: U6N325, U6N3P1
Pockets: 6 · best druggability 0.77

Structure

solution nmr · 2 distinct chains · 40% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Trigger factor (EC 5.2.1.8)	protein	432	47% helix, 22% strand	U6N325
B	Alkaline phosphatase	protein	91	8% helix, 0% strand	U6N3P1

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	128	0.77	0.95	20	empty
2	544	0.63	0.75	53	empty
3	124	0.62	0.85	23	empty
4	93	0.37	0.76	16	empty
5	61	0.35	0.77	15	empty

Interfaces

1 interface between chains.

A–B · 3136 Å² buried · 73 hydrogen bonds · protein-protein

Compared structures

2MLX · NMR structure of E. coli Trigger Factor in complex with unfolded PhoA220-310 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt U6N325
Every structure of UniProt U6N3P1
Elsewhere: RCSB PDB 2MLX · PDBe 2MLX · UniProt U6N325 · UniProt U6N3P1

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