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Solution structure of tandem rrm domains of cytoplasmic polyadenylation element binding protein 4 (CPEB4) in complex with RNA
Analyse Solution structure of tandem rrm domains of cytoplasmic polyadenylation element… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2MKI
- Type
- protein + RNA
- Length
- 208 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytoplasmic polyadenylation element-binding protein 4; RNA (5'-R(*CP*UP*UP*UP*A)-3')
- UniProt
- Q17RY0
- Pockets
- 2 · best druggability 0.52
Structure
solution nmr · 2 distinct chains · 18% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytoplasmic polyadenylation element-binding protein 4 | protein | 203 | 18% helix, 28% strand | Q17RY0 |
| B | RNA (5'-R(*CP*UP*UP*UP*A)-3') | rna | 5 | — | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 121 | 0.52 | 0.82 | 22 | empty |
| 2 | 51 | 0.29 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 844 Ų buried · 19 hydrogen bonds · protein-nucleic
Compared structures
- 2MKI · Solution structure of tandem RRM domains of cytoplasmic polyadenylation element binding… · the same entry in another collection · chain A against A, TM-score 1.00
- Q17RY0 · AlphaFold monomer V2.0 prediction for cytoplasmic polyadenylation element-binding protein… · a predicted model of the same protein · chain A against A, TM-score 0.66
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q17RY0
- Elsewhere: RCSB PDB 2MKI · PDBe 2MKI · UniProt Q17RY0
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