Research workbench
Solution structures of second bromodomain of BRD4 with di-acetylated twist peptide
Analyse Solution structures of second bromodomain of BRD4 with di-acetylated twist… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2MJV
- Type
- protein
- Length
- 140 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Twist-related protein 1; Bromodomain-containing protein 4
- UniProt
- Q15672, O60885
Structure
solution nmr · 2 distinct chains · 48% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Twist-related protein 1 | protein | 12 | 0% helix, 0% strand | Q15672 |
| B | Bromodomain-containing protein 4 | protein | 128 | 52% helix, 0% strand | O60885 |
Interfaces
1 interface between chains.
- A–B · 651 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (acetylation).
Compared structures
- 2MJV · Solution structures of second bromodomain of Brd4 with di-acetylated Twist peptide · the same entry in another collection · chain A against A, TM-score 1.00
- O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain B against A, TM-score 0.79
- Q15672 · AlphaFold monomer V2.0 prediction for twist-related protein 1 (Q15672) · a predicted model of the same protein · chain A against A, TM-score 0.25
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15672
- Every structure of UniProt O60885
- Elsewhere: RCSB PDB 2MJV · PDBe 2MJV · UniProt Q15672 · UniProt O60885
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