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Solution structure of BCL-xl containing the ALPHA1-ALPHA2 disordered loop determined with selective isotope labelling of I,L,V sidechains

Analyse Solution structure of BCL-xl containing the ALPHA1-ALPHA2 disordered loop… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2ME9
Type: protein
Length: 212 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: BCL-2-like protein 1
UniProt: Q07817
Pockets: 4 · best druggability 0.59

Structure

solution nmr · 1 distinct chain · 48% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	BCL-2-like protein 1	protein	212	48% helix, 0% strand	Q07817

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	183	0.59	0.81	34	empty
2	77	0.46	0.81	14	empty
3	118	0.45	0.78	18	empty
4	54	0.40	0.81	14	empty

Compared structures

2ME9 · Solution structure of BCL-xL containing the alpha1-alpha2 disordered loop determined with… · the same entry in another collection · chain A against A, TM-score 1.00
Q07817 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 1 (Q07817) · a predicted model of the same protein · chain A against A, TM-score 0.56

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07817
Elsewhere: RCSB PDB 2ME9 · PDBe 2ME9 · UniProt Q07817

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