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Solution structure of BCL-xl in its P53-bound conformation determined with selective isotope labelling of I,L,V sidechains

Analyse Solution structure of BCL-xl in its P53-bound conformation determined with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2ME8
Type: protein
Length: 212 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: BCL-2-like protein 1
UniProt: Q07817
Pockets: 5 · best druggability 0.68

Structure

solution nmr · 1 distinct chain · 49% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	BCL-2-like protein 1	protein	212	49% helix, 0% strand	Q07817

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	279	0.68	0.83	39	empty
2	52	0.55	0.90	14	empty
3	205	0.49	0.75	20	empty
4	60	0.45	0.84	15	empty
5	144	0.44	0.76	20	empty

Compared structures

2ME8 · Solution Structure of BCL-xL in its p53-bound conformation determined with selective… · the same entry in another collection · chain A against A, TM-score 1.00
Q07817 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 1 (Q07817) · a predicted model of the same protein · chain A against A, TM-score 0.56

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07817
Elsewhere: RCSB PDB 2ME8 · PDBe 2ME8 · UniProt Q07817

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