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NMR structure of the homeodomain transcription factor GBX1 from homo sapiens solved in the presence of the DNA sequence cgactaattagtcg

Analyse NMR structure of the homeodomain transcription factor GBX1 from homo sapiens… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2ME0
Type: protein
Length: 71 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Homeobox protein gbx-1
UniProt: Q14549
Pockets: 1 · best druggability 0.52

Structure

solution nmr · 1 distinct chain · 51% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Homeobox protein gbx-1	protein	71	51% helix, 0% strand	Q14549

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	253	0.52	0.75	30	empty

Compared structures

2ME0 · NMR Structure of the homeodomain transcription factor Gbx1 from Homo sapiens solved in… · the same entry in another collection · chain A against A, TM-score 1.00
Q14549 · AlphaFold monomer V2.0 prediction for homeobox protein gbx-1 (Q14549) · a predicted model of the same protein · chain A against A, TM-score 0.58

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14549
Elsewhere: RCSB PDB 2ME0 · PDBe 2ME0 · UniProt Q14549

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