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Structure of SRSF1 RRM2 in complex with the RNA 5'-ugaaggac-3'

Analyse Structure of SRSF1 RRM2 in complex with the RNA 5'-ugaaggac-3' in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2M8D
Type: protein + RNA
Length: 99 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA (5'-R(*UP*GP*AP*AP*GP*GP*AP*C)-3'); SERINE/ARGININE-rich splicing factor 1
UniProt: Q07955
Pockets: 1 · best druggability 0.28

Structure

solution nmr · 2 distinct chains · 16% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA (5'-R(UPGPAPAPGPGPAPC)-3')	rna	8	—	—
B	SERINE/ARGININE-rich splicing factor 1	protein	91	16% helix, 31% strand	Q07955

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	51	0.28	0.76	12	empty

Interfaces

1 interface between chains.

A–B · 827 Å² buried · 33 hydrogen bonds · protein-nucleic

Compared structures

2M8D · Structure of SRSF1 RRM2 in complex with the RNA 5'-UGAAGGAC-3' · the same entry in another collection · chain A against A, TM-score 1.00
Q07955 · AlphaFold monomer V2.0 prediction for SERINE/ARGININE-rich splicing factor 1 (Q07955) · a predicted model of the same protein · chain B against A, TM-score 0.80

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07955
Elsewhere: RCSB PDB 2M8D · PDBe 2M8D · UniProt Q07955

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