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Solution structure of HDM2 with engineered cyclotide

Analyse Solution structure of HDM2 with engineered cyclotide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2M86
Type: protein
Length: 134 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mco-pmi; E3 ubiquitin-protein ligase MDM2
UniProt: Q00987
Pockets: 1 · best druggability 0.82

Structure

solution nmr · 2 distinct chains · 33% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mco-pmi	protein	51	14% helix, 8% strand	—
B	E3 ubiquitin-protein ligase MDM2	protein	83	45% helix, 11% strand	Q00987

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	172	0.82	0.96	28	empty

Interfaces

1 interface between chains.

A–B · 775 Å² buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

2M86 · Solution structure of Hdm2 with engineered cyclotide · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q00987
Elsewhere: RCSB PDB 2M86 · PDBe 2M86 · UniProt Q00987

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