Research workbench
Orthorhombic crystal form of heat shock locus U (hslu) from escherichia COLI
Analyse Orthorhombic crystal form of heat shock locus U (hslu) from escherichia COLI in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1DO0
- Type
- protein
- Length
- 2,436 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (heat shock locus U)
- UniProt
- P0A6H5
- Ligands
- ATP, MG, SO4
- Pockets
- 20 · best druggability 0.87
Structure
x-ray diffraction · 1 distinct chain · 56% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Protein (heat shock locus U) | protein | 406 | 56% helix, 11% strand | P0A6H5 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · 4 copies · chains A, B, C, D, E, F
- MG · Magnesium ion · metal · 2 copies · chains B, E
- SO4 · Sulfate ion · ion · 2 copies · chains C, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1135 | 0.87 | 0.88 | 127 | MG, ATP |
| 2 | 1129 | 0.86 | 0.87 | 120 | ATP |
| 3 | 1042 | 0.85 | 0.86 | 99 | ATP |
| 4 | 1150 | 0.84 | 0.85 | 104 | MG, ATP |
| 5 | 949 | 0.80 | 0.82 | 94 | SO4 |
Interfaces
9 interfaces between chains.
- E–F · 2602 Ų buried · 28 hydrogen bonds · protein-protein
- B–C · 2558 Ų buried · 30 hydrogen bonds · protein-protein
- D–E · 2442 Ų buried · 25 hydrogen bonds · protein-protein
- A–B · 2351 Ų buried · 25 hydrogen bonds · protein-protein
- A–F · 1831 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 1DO0 · Orthorhombic crystal form of heat shock locus U (hslu) from escherichia COLI · the same entry in another collection · chain C against C, TM-score 1.00
- P0A6H5 · AlphaFold monomer V2.0 prediction for ATP-dependent protease ATPase subunit hslu (P0A6H5) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A6H5
- Elsewhere: RCSB PDB 1DO0 · PDBe 1DO0 · UniProt P0A6H5
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