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Ticam-2 tir domain

Analyse Ticam-2 tir domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2M1W
Type: protein
Length: 166 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tir domain-containing adapter molecule 2
UniProt: Q86XR7
Pockets: 2 · best druggability 0.67

Structure

solution nmr · 1 distinct chain · 42% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tir domain-containing adapter molecule 2	protein	166	42% helix, 8% strand	Q86XR7

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	478	0.67	0.78	47	empty
2	82	0.39	0.77	16	empty

Compared structures

2M1W · TICAM-2 TIR domain · the same entry in another collection · chain A against A, TM-score 1.00
Q86XR7 · AlphaFold monomer V2.0 prediction for tir domain-containing adapter molecule 2 (Q86XR7) · a predicted model of the same protein · chain A against A, TM-score 0.75

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q86XR7
Elsewhere: RCSB PDB 2M1W · PDBe 2M1W · UniProt Q86XR7

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