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Solution structure and dynamics of human S100A14

Analyse Solution structure and dynamics of human S100A14 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2M0R
Type: protein
Length: 208 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein S100-A14
UniProt: Q9HCY8
Pockets: 6 · best druggability 0.70

Structure

solution nmr · 1 distinct chain · 47% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Protein S100-A14	protein	104	47% helix, 0% strand	Q9HCY8

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	104	0.70	0.91	21	empty
2	68	0.69	0.95	22	empty
3	63	0.33	0.77	14	empty
4	66	0.33	0.76	14	empty
5	65	0.30	0.75	15	empty

Interfaces

1 interface between chains.

A–B · 2022 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

2M0R · Solution structure and dynamics of human S100A14 · the same entry in another collection · chain A against A, TM-score 1.00
Q9HCY8 · AlphaFold monomer V2.0 prediction for protein S100-A14 (Q9HCY8) · a predicted model of the same protein · chain A against A, TM-score 0.66

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HCY8
Elsewhere: RCSB PDB 2M0R · PDBe 2M0R · UniProt Q9HCY8

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