Research workbench
Solution structure of polymerase-interacting domain of human REV1 in complex with translesional synthesis polymerase kappa
Analyse Solution structure of polymerase-interacting domain of human REV1 in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2LSI
- Type
- protein
- Length
- 116 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA repair protein REV1; DNA polymerase kappa
- EC
- 2.7.7.-, 2.7.7.7
- UniProt
- Q9UBZ9, Q9UBT6
- Pockets
- 1 · best druggability 0.32
Structure
solution nmr · 2 distinct chains · 66% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA repair protein REV1 (EC 2.7.7.-) | protein | 99 | 69% helix, 2% strand | Q9UBZ9 |
| B | DNA polymerase kappa (EC 2.7.7.7) | protein | 17 | 47% helix, 0% strand | Q9UBT6 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 66 | 0.32 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 602 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 2LSI · Solution structure of polymerase-interacting domain of human Rev1 in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UBZ9 · AlphaFold monomer V2.0 prediction for DNA repair protein REV1 (Q9UBZ9) · a predicted model of the same protein · chain A against A, TM-score 0.94
- Q9UBT6 · AlphaFold monomer V2.0 prediction for DNA polymerase kappa (Q9UBT6) · a predicted model of the same protein · chain B against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UBZ9
- Every structure of UniProt Q9UBT6
- Elsewhere: RCSB PDB 2LSI · PDBe 2LSI · UniProt Q9UBZ9 · UniProt Q9UBT6
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