Research workbench
Structure of the complex of the central activation domain of GCN4 bound to the mediator co-activator domain 1 of GAL11/MED15
Analyse Structure of the complex of the central activation domain of GCN4 bound to the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2LPB
- Type
- protein
- Length
- 115 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mediator of RNA polymerase II transcription subunit 15; General control protein GCN4
- UniProt
- P19659, P03069
- Pockets
- 2 · best druggability 0.66
Structure
solution nmr · 2 distinct chains · 45% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mediator of RNA polymerase II transcription subunit 15 | protein | 81 | 56% helix, 2% strand | P19659 |
| B | General control protein GCN4 | protein | 34 | 21% helix, 0% strand | P03069 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 620 | 0.66 | 0.76 | 46 | empty |
| 2 | 80 | 0.54 | 0.85 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 742 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 2LPB · Structure of the complex of the central activation domain of Gcn4 bound to the mediator… · the same entry in another collection · chain A against A, TM-score 1.00
- P19659 · AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit… · a predicted model of the same protein · chain A against A, TM-score 0.73
- P03069 · AlphaFold monomer V2.0 prediction for general control transcription factor GCN4 (P03069) · a predicted model of the same protein · chain B against A, TM-score 0.31
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19659
- Every structure of UniProt P03069
- Elsewhere: RCSB PDB 2LPB · PDBe 2LPB · UniProt P19659 · UniProt P03069
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