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The solution structure of homeodomain-protein complex

Analyse The solution structure of homeodomain-protein complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2LP0
Type: protein
Length: 80 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Homeobox protein hox-C9; Geminin
UniProt: P31274, O75496
Pockets: 1 · best druggability 0.33

Structure

solution nmr · 2 distinct chains · 49% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Homeobox protein hox-C9	protein	60	65% helix, 0% strand	P31274
B	Geminin	protein	20	0% helix, 0% strand	O75496

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	51	0.33	0.78	12	empty

Interfaces

1 interface between chains.

A–B · 775 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

2LP0 · The solution structure of homeodomain-protein complex · the same entry in another collection · chain A against A, TM-score 1.00
P31274 · AlphaFold monomer V2.0 prediction for homeobox protein hox-C9 (P31274) · a predicted model of the same protein · chain A against A, TM-score 0.77
O75496 · AlphaFold monomer V2.0 prediction for geminin (O75496) · a predicted model of the same protein · chain B against A, TM-score 0.20

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31274
Every structure of UniProt O75496
Elsewhere: RCSB PDB 2LP0 · PDBe 2LP0 · UniProt P31274 · UniProt O75496

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