Research workbench
NMR structure of the complex between the pH domain of the TFB1 subunit from tfiih and RAD2
Analyse NMR structure of the complex between the pH domain of the TFB1 subunit from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2LOX
- Type
- protein
- Length
- 135 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA polymerase II transcription factor B subunit 1; DNA repair protein RAD2
- EC
- 3.1.-.-
- UniProt
- P32776, P07276
- Pockets
- 1 · best druggability 0.37
Structure
solution nmr · 2 distinct chains · 16% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA polymerase II transcription factor B subunit 1 | protein | 115 | 18% helix, 36% strand | P32776 |
| B | DNA repair protein RAD2 (EC 3.1.-.-) | protein | 20 | 0% helix, 5% strand | P07276 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 95 | 0.37 | 0.75 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 727 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 2LOX · NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and Rad2 · the same entry in another collection · chain A against A, TM-score 1.00
- P32776 · AlphaFold monomer V2.0 prediction for general transcription and DNA repair factor iih… · a predicted model of the same protein · chain A against A, TM-score 0.81
- P07276 · AlphaFold monomer V2.0 prediction for DNA repair protein RAD2 (P07276) · a predicted model of the same protein · chain B against A, TM-score 0.22
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32776
- Every structure of UniProt P07276
- Elsewhere: RCSB PDB 2LOX · PDBe 2LOX · UniProt P32776 · UniProt P07276
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