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PDZ domain of cal (cystic fibrosis transmembrane regulator-associated ligand)

Analyse PDZ domain of cal (cystic fibrosis transmembrane regulator-associated ligand) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
2LOB
Type
protein
Length
94 residues
Chains
2
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Golgi-associated PDZ and coiled-coil motif-containing protein; Cystic fibrosis…
EC
3.6.3.49
UniProt
Q9HD26, P13569

Structure

solution nmr · 2 distinct chains · 14% helix, 39% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AGolgi-associated PDZ and coiled-coil motif-containing proteinprotein8615% helix, 41% strandQ9HD26
BCystic fibrosis transmembrane conductance regulator (EC 3.6.3.49)protein80% helix, 25% strandP13569

Interfaces

1 interface between chains.

  • A–B · 542 Ų buried · 26 hydrogen bonds · protein-protein

Compared structures

  • 2LOB · PDZ Domain of CAL (Cystic Fibrosis Transmembrane Regulator-Associated Ligand) · the same entry in another collection · chain A against A, TM-score 1.00
  • Q9HD26 · AlphaFold monomer V2.0 prediction for golgi-associated PDZ and coiled-coil… · a predicted model of the same protein · chain A against A, TM-score 0.79
  • P13569 · AlphaFold monomer V2.0 prediction for cystic fibrosis transmembrane conductance regulator… · a predicted model of the same protein · chain B against A, TM-score 0.34

Analyse

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