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Solution structure of VAV2 SH2 domain

Analyse Solution structure of VAV2 SH2 domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2LNX
Type: protein
Length: 113 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Guanine nucleotide exchange factor VAV2
UniProt: P52735
Pockets: 1 · best druggability 0.61

Structure

solution nmr · 1 distinct chain · 20% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Guanine nucleotide exchange factor VAV2	protein	113	20% helix, 27% strand	P52735

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	79	0.61	0.89	20	empty

Compared structures

2LNX · Solution structure of Vav2 SH2 domain · the same entry in another collection · chain A against A, TM-score 1.00
P52735 · AlphaFold monomer V2.0 prediction for guanine nucleotide exchange factor VAV2 (P52735) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52735
Elsewhere: RCSB PDB 2LNX · PDBe 2LNX · UniProt P52735

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