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Structure of human CXCR1 in phospholipid bilayers

Analyse Structure of human CXCR1 in phospholipid bilayers in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2LNL
Type: protein
Length: 296 residues
Chains: 1
Method: solid-state nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: C-X-C chemokine receptor type 1
UniProt: P25024
Pockets: 5 · best druggability 0.81

Structure

solid-state nmr · 1 distinct chain · 71% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	C-X-C chemokine receptor type 1	protein	296	71% helix, 0% strand	P25024

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	210	0.81	0.94	34	empty
2	77	0.73	0.97	22	empty
3	137	0.68	0.88	23	empty
4	115	0.43	0.77	19	empty
5	82	0.34	0.75	16	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2LNL · Structure of human CXCR1 in phospholipid bilayers · the same entry in another collection · chain A against A, TM-score 1.00
P25024 · AlphaFold monomer V2.0 prediction for C-X-C chemokine receptor type 1 (P25024) · a predicted model of the same protein · chain A against A, TM-score 0.61

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25024
Elsewhere: RCSB PDB 2LNL · PDBe 2LNL · UniProt P25024

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