Research workbench
Structural basis for molecular interactions involving mrg domains: implications in chromatin biology
Analyse Structural basis for molecular interactions involving mrg domains: implications… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2LKM
- Type
- protein
- Length
- 214 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phd finger protein 12; Mortality factor 4-like protein 1
- UniProt
- Q96QT6, Q9UBU8
- Pockets
- 3 · best druggability 0.61
Structure
solution nmr · 2 distinct chains · 51% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phd finger protein 12 | protein | 42 | 26% helix, 0% strand | Q96QT6 |
| B | Mortality factor 4-like protein 1 | protein | 172 | 58% helix, 3% strand | Q9UBU8 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 167 | 0.61 | 0.83 | 26 | empty |
| 2 | 88 | 0.33 | 0.74 | 15 | empty |
| 3 | 51 | 0.25 | 0.72 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1570 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 2LKM · Structural Basis for Molecular Interactions Involving MRG Domains: Implications in… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UBU8 · AlphaFold monomer V2.0 prediction for mortality factor 4-like protein 1 (Q9UBU8) · a predicted model of the same protein · chain B against A, TM-score 0.91
- Q96QT6 · AlphaFold monomer V2.0 prediction for phd finger protein 12 (Q96QT6) · a predicted model of the same protein · chain A against A, TM-score 0.43
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96QT6
- Every structure of UniProt Q9UBU8
- Elsewhere: RCSB PDB 2LKM · PDBe 2LKM · UniProt Q96QT6 · UniProt Q9UBU8
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