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Metal binding domain of rat beta-amyloid

Analyse Metal binding domain of rat beta-amyloid in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2LI9
Type: protein
Length: 32 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Amyloid beta A4 protein
UniProt: P08592
Ligands: ACE, ZN, NH2

Structure

solution nmr · 1 distinct chain · 0% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Amyloid beta A4 protein	protein	16	0% helix, 0% strand	P08592

Ligands and binding sites

ACE · Acetyl group · ligand · 2 copies · chains A, B
ZN · Zinc ion · metal · chains A, B
NH2 · Amino group · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 417 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 covalent (covalent ligand).

Compared structures

2LI9 · Metal binding domain of rat beta-amyloid · the same entry in another collection · chain A against A, TM-score 1.00
P08592 · AlphaFold monomer V2.0 prediction for amyloid-beta A4 protein (P08592) · a predicted model of the same protein · chain A against A, TM-score 0.20

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08592
Elsewhere: RCSB PDB 2LI9 · PDBe 2LI9 · UniProt P08592

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