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Solution NMR structure of the helix-loop-helix domain of human ID3 protein, northeast structural genomics consortium target HR3111A

Analyse Solution NMR structure of the helix-loop-helix domain of human ID3 protein… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2LFH
Type: protein
Length: 136 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA-binding protein inhibitor id-3
UniProt: Q02535
Pockets: 2 · best druggability 0.44

Structure

solution nmr · 1 distinct chain · 41% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	DNA-binding protein inhibitor id-3	protein	68	41% helix, 1% strand	Q02535

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	103	0.44	0.78	14	empty
2	70	0.37	0.78	20	empty

Interfaces

1 interface between chains.

A–B · 2173 Å² buried · 30 hydrogen bonds · protein-protein

Compared structures

2LFH · Solution NMR Structure of the Helix-loop-Helix Domain of Human ID3 Protein, Northeast… · the same entry in another collection · chain A against A, TM-score 1.00
Q02535 · AlphaFold monomer V2.0 prediction for DNA-binding protein inhibitor id-3 (Q02535) · a predicted model of the same protein · chain A against A, TM-score 0.55

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q02535
Elsewhere: RCSB PDB 2LFH · PDBe 2LFH · UniProt Q02535

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