Research workbench
Solution structure of the MSIN3A PAH3-SAP30 sid complex
Analyse Solution structure of the MSIN3A PAH3-SAP30 sid complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2LD7
- Type
- protein
- Length
- 169 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone deacetylase complex subunit SAP30; Paired amphipathic helix protein SIN3A
- UniProt
- O88574, Q60520
- Pockets
- 1 · best druggability 0.32
Structure
solution nmr · 2 distinct chains · 51% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone deacetylase complex subunit SAP30 | protein | 94 | 38% helix, 0% strand | O88574 |
| B | Paired amphipathic helix protein SIN3A | protein | 75 | 67% helix, 0% strand | Q60520 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.32 | 0.76 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1704 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 2LD7 · Solution structure of the mSin3A PAH3-SAP30 SID complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q60520 · AlphaFold monomer V2.0 prediction for paired amphipathic helix protein SIN3A (Q60520) · a predicted model of the same protein · chain B against A, TM-score 0.88
- O88574 · AlphaFold monomer V2.0 prediction for histone deacetylase complex subunit SAP30 (O88574) · a predicted model of the same protein · chain A against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O88574
- Every structure of UniProt Q60520
- Elsewhere: RCSB PDB 2LD7 · PDBe 2LD7 · UniProt O88574 · UniProt Q60520
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