Research workbench
Structure of the HIV-1 frameshift site RNA bound to a small molecule inhibitor of viral replication
Analyse Structure of the HIV-1 frameshift site RNA bound to a small molecule inhibitor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2L94
- Type
- RNA
- Length
- 45 nucleotides
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA_(45-mer)
- Ligands
- L94
- Pockets
- 2 · best druggability 0.47
Structure
solution nmr · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA_(45-mer) | rna | 45 | — | — |
Ligands and binding sites
- L94 · N'-{(Z)-amino[4-(amino{[3-(dimethylammonio) propyl]iminio}methyl)phenyl]methylidene}-N,N-dimethylpropane-1,3-diaminium · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 282 | 0.47 | 0.73 | 22 | L94 |
| 2 | 96 | 0.30 | 0.73 | 13 | empty |
Compared structures
- 2L94 · Structure of the HIV-1 frameshift site RNA bound to a small molecule inhibitor of viral… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2L94 · PDBe 2L94
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