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Solution NMR structure of apo-calmodulin in complex with the iq motif of human cardiac sodium channel NAV1.5

Analyse Solution NMR structure of apo-calmodulin in complex with the iq motif of human… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2L53
Type: protein
Length: 179 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calmodulin; Voltage-gated sodium channel type V alpha isoform B variant
UniProt: P62158, Q59H93
Pockets: 1 · best druggability 0.29

Structure

solution nmr · 2 distinct chains · 60% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Calmodulin	protein	148	58% helix, 7% strand	P62158
B	Voltage-gated sodium channel type V alpha isoform B variant	protein	31	68% helix, 0% strand	Q59H93

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	54	0.29	0.75	13	empty

Interfaces

1 interface between chains.

A–B · 991 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

2L53 · Solution NMR Structure of apo-calmodulin in complex with the IQ motif of Human Cardiac… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62158
Every structure of UniProt Q59H93
Elsewhere: RCSB PDB 2L53 · PDBe 2L53 · UniProt P62158 · UniProt Q59H93

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