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Solution structure of mouse il-6

Analyse Solution structure of mouse il-6 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2L3Y
Type: protein
Length: 184 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interleukin-6
UniProt: P08505
Pockets: 6 · best druggability 0.62

Structure

solution nmr · 1 distinct chain · 56% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Interleukin-6	protein	184	56% helix, 0% strand	P08505

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	359	0.62	0.78	42	empty
2	247	0.60	0.80	32	empty
3	83	0.40	0.77	11	empty
4	79	0.39	0.78	18	empty
5	70	0.36	0.77	11	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2L3Y · Solution structure of mouse IL-6 · the same entry in another collection · chain A against A, TM-score 1.00
P08505 · AlphaFold monomer V2.0 prediction for interleukin-6 (P08505) · a predicted model of the same protein · chain A against A, TM-score 0.70

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08505
Elsewhere: RCSB PDB 2L3Y · PDBe 2L3Y · UniProt P08505

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