Research workbench
The solution structure of the ADAR2 dsrbm-RNA complex reveals a sequence-specific read out of the minor groove
Analyse The solution structure of the ADAR2 dsrbm-RNA complex reveals a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2L3J
- Type
- protein + RNA
- Length
- 307 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Double-stranded RNA-specific editase 1; RNA (71-mer)
- EC
- 3.5.-.-
- UniProt
- P51400
- Pockets
- 3 · best druggability 0.53
Structure
solution nmr · 2 distinct chains · 22% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Double-stranded RNA-specific editase 1 (EC 3.5.-.-) | protein | 236 | 22% helix, 18% strand | P51400 |
| B | RNA (71-mer) | rna | 71 | — | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 361 | 0.53 | 0.74 | 20 | empty |
| 2 | 322 | 0.49 | 0.73 | 20 | empty |
| 3 | 73 | 0.37 | 0.78 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1342 Ų buried · 22 hydrogen bonds · protein-nucleic
Compared structures
- 2L3J · The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific read… · the same entry in another collection · chain A against A, TM-score 1.00
- P51400 · AlphaFold monomer V2.0 prediction for double-stranded RNA-specific editase 1 (P51400) · a predicted model of the same protein · chain A against A, TM-score 0.34
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P51400
- Elsewhere: RCSB PDB 2L3J · PDBe 2L3J · UniProt P51400
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