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Solution NMR structure of the R/G stem loop RNA-ADAR2 DSRBM2 complex

Analyse Solution NMR structure of the R/G stem loop RNA-ADAR2 DSRBM2 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2L2K
Type: protein + RNA
Length: 113 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Adenosine deaminase; RNA (42-mer)
EC: 3.5.-.-
UniProt: Q3UHM7
Pockets: 1 · best druggability 0.54

Structure

solution nmr · 2 distinct chains · 34% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Adenosine deaminase (EC 3.5.-.-)	protein	71	34% helix, 32% strand	Q3UHM7
A	RNA (42-mer)	rna	42	—	—

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	381	0.54	0.74	29	empty

Interfaces

1 interface between chains.

B–A · 937 Å² buried · 23 hydrogen bonds · protein-nucleic

Compared structures

2L2K · Solution NMR structure of the R/G STEM LOOP RNA-ADAR2 DSRBM2 Complex · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q3UHM7
Elsewhere: RCSB PDB 2L2K · PDBe 2L2K · UniProt Q3UHM7

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