Research workbench
Complex structure of E4 mutant human IGF2R domain 11 bound to igf-II
Analyse Complex structure of E4 mutant human IGF2R domain 11 bound to igf-II in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2L29
- Type
- protein
- Length
- 209 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin-like growth factor 2 receptor variant; Insulin-like growth factor II
- UniProt
- Q59EZ3, P01344
- Pockets
- 2 · best druggability 0.58
Structure
solution nmr · 2 distinct chains · 12% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin-like growth factor 2 receptor variant | protein | 142 | 2% helix, 44% strand | Q59EZ3 |
| B | Insulin-like growth factor II | protein | 67 | 33% helix, 1% strand | P01344 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 86 | 0.58 | 0.87 | 25 | empty |
| 2 | 81 | 0.35 | 0.76 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 775 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 2L29 · Complex structure of E4 mutant human IGF2R domain 11 bound to IGF-II · the same entry in another collection · chain B against B, TM-score 1.00
- P01344 · AlphaFold monomer V2.0 prediction for insulin-like growth factor II (P01344) · a predicted model of the same protein · chain B against A, TM-score 0.58
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q59EZ3
- Every structure of UniProt P01344
- Elsewhere: RCSB PDB 2L29 · PDBe 2L29 · UniProt Q59EZ3 · UniProt P01344
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