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Structure-functional analysis of mammalian MSRB2 protein

Analyse Structure-functional analysis of mammalian MSRB2 protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2L1U
Type: protein
Length: 143 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Methionine-R-sulfoxide reductase B2, mitochondrial
EC: 1.8.4.-
UniProt: Q78J03
Ligands: ZN
Pockets: 2 · best druggability 0.64

Structure

solution nmr · 1 distinct chain · 17% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Methionine-R-sulfoxide reductase B2, mitochondrial (EC 1.8.4.-)	protein	143	17% helix, 27% strand	Q78J03

Ligands and binding sites

ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	464	0.64	0.77	42	empty
2	179	0.56	0.80	37	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

2L1U · Structure-Functional Analysis of Mammalian MsrB2 protein · the same entry in another collection · chain A against A, TM-score 1.00
Q78J03 · AlphaFold monomer V2.0 prediction for methionine-R-sulfoxide reductase B2, mitochondrial… · a predicted model of the same protein · chain A against A, TM-score 0.54

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q78J03
Elsewhere: RCSB PDB 2L1U · PDBe 2L1U · UniProt Q78J03

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